About dbCRID

  • dbCRID (Database of Chromosomal Rearrangements In Diseases) is the largest database of curated database of human Chromosome rearrangements and associated diseases.
  • Current release: v 0.9 (06/30/2010).
  • Please direct questions and comments to dbCRID@biolead.org.

    • Related Databases

  • AtlasGeneticsOncology, Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • ChimerDB 2.0, A knowledgebase for fusion genes updated
  • CytoD 1.0, A database of cytogenetic abnormalities.
  • DACRO, A disease-Associated Chromosomal Rearrangements Online.
  • Decipher, , A Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
  • HYBRIDdb,A database of hybrid genes in the human genome.
  • Mitelman, A database of Chromosome Aberrations and Gene Fusions in Cancer.
  • SKY/M-FISH &CGH, A public platform for investigators to share and compare their molecular cytogenetic data.
  • TICdb, A database of Translocation breakpoints In Cancer.

    • References

  • Kong F, Zhu J, Wu J, Peng J, Wang Y, Wang Q, Fu S, Yuan L and Li T: dbCRID: a database of chromosomal rearrangements in human diseases. Nucleic Acids Res. [PubMed] [Full-text]
    • Event ID: 11291 ( Case ID: 12032 )
    Symptom: A unilateral cleft lip, midline cleft palate, hypertelorism, a broad and flat nasal bridge, small low-set ears, preauricular pits, proximally positioned thumbs, short distal phalanges, fifth digit clinodactyly, amptodactyly, and a hemangioma
    Event Information
    Precision: A
    Chromosome Rearrangement Type: Reciprocal Translocation
    Chromosome: X, 1
    Karyotype: t(X;1)(q28;q21)
    Breakpoints Information:
    First Breakpoint:
    Location: q28
    Exact position: ChrX: 153991521bp
    This breakpoint occurs in intron1 of NM_001142463.1.
    Second Breakpoint:
    Location: q21
    Exact position: Chr1: 155119865bp
    This breakpoint occurs in an intergenic region
    Junction Sequence(5'):
    TGGCAAGGGCGCGAGAGTGGGAGCCCCTCGCGGTGACTTGGCATGATGGGGCTCGGCCCTCTCACCTCCCTGGGGTCCGGGTCGCCGTCGAAAGACATCTATGTATCTATTAAATAGATACATATTTATGTATCTATTAAATAGATACATATATTATATATATGTAAATTTTAGCTGGCATGGTAGAGCATGCCTATAGT
    Junction Sequence(3'):
    TCAAAAAAAATTTTTTTAATATATATTTTATTTAAATATGTATCTATAAAATATATACATATTTAAATATGTATCTATTAAATAGATACATATTTAAATATGCCGTGCTGCCCACCCCGCGGTGGCGTGGGACGTGGCAGTGTCTGTGCTGCTGCCAGCCCGGACGCCGCCGTTACAGCTCCATGCGACTAGGGGAGCAA
    The Junction Sequence is Inferred.
    Note: Green and Blue color indicate 5' and 3' sequence according to the breakpoint.
    Experimental Method: FISH, PCR, DNA sequencing
    Reference Information
    PubMed ID: 19215059
    Authors: Cottrell CE,Sommer A,Wenger GD,Bullard S,Busch T,Krahn KN,Lidral AC,Gastier-Foster JM
    Journal: American journal of medical genetics. Part A
    Go to Genome Browser ( Click the image )