About dbCRID

  • dbCRID (Database of Chromosomal Rearrangements In Diseases) is the largest database of curated database of human Chromosome rearrangements and associated diseases.
  • Current release: v 0.9 (06/30/2010).
  • Please direct questions and comments to dbCRID@biolead.org.

    • Related Databases

  • AtlasGeneticsOncology, Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • ChimerDB 2.0, A knowledgebase for fusion genes updated
  • CytoD 1.0, A database of cytogenetic abnormalities.
  • DACRO, A disease-Associated Chromosomal Rearrangements Online.
  • Decipher, , A Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
  • HYBRIDdb,A database of hybrid genes in the human genome.
  • Mitelman, A database of Chromosome Aberrations and Gene Fusions in Cancer.
  • SKY/M-FISH &CGH, A public platform for investigators to share and compare their molecular cytogenetic data.
  • TICdb, A database of Translocation breakpoints In Cancer.

    • References

  • Kong F, Zhu J, Wu J, Peng J, Wang Y, Wang Q, Fu S, Yuan L and Li T: dbCRID: a database of chromosomal rearrangements in human diseases. Nucleic Acids Res. [PubMed] [Full-text]
    • Event ID: 10274 ( Case ID: 11428 )
    Disease: Pelizaeus-Merzbacher Disease ( DOID: 3210 ) All events related to this disease.
    Event Information
    Precision: A
    Chromosome Rearrangement Type: Duplication
    Chromosome: X
    Karyotype: dup(X)(q22.2q22.2)
    Breakpoints Information:
    Insertion Breakpoint:
    Location: q22.2
    Exact position: ChrX: 103223416bp
    This breakpoint occurs in an intergenic region
    First Breakpoint:
    Location: q22.2
    Exact position: ChrX: 102943390bp
    This breakpoint occurs in an intergenic region
    Second Breakpoint:
    Location: q22.2
    Exact position: ChrX: 103223416bp
    This breakpoint occurs in an intergenic region
    Length of Duplication Segment is 280026bp.
    Junction Sequence(5'):
    TGAATCAGGGGTATATATTTTTTTTTTCCAAATAAGCAAGGATTGAGATTTATGTCCCTGAATCCATCTATTATCTGCAAAACTGGCAGTACCAGGGCTTTGCTCGCAACTCACCCAAACTGAAAATACAGATAGCTGTTCCGTCAGTAAAGATAGATAAGAACTCATCAGTAAAACCTGGACCCTGGTATTGAAAACTG
    Junction Sequence(3'):
    TGAATCAGGGGTATATATTTTTTTTTTCCAAATAAGCAAGGATTGAGATTTATGTCCCTGAATCCATCTATTATCTGCAAAACTGGCAGTACCAGGGCTTTTGTTATAGCAGTTGTATTTATAGGGAAAGGAAAAGGCTGGAGTTAAATGATTGTCTTCTTTTATGCATTAACATCCCTTGAAAATCACTGGTCAGTGGC
    The Junction Sequence is Inferred.
    Note: Green and Blue color indicate 5' and 3' sequence according to the breakpoint.
    Experimental Method: FISH, LR-PCR, DNA sequencing
    Reference Information
    PubMed ID: 16380909
    Authors: Woodward KJ,Cundall M,Sperle K,Sistermans EA,Ross M,Howell G,Gribble SM,Burford DC,Carter NP,Hobson DL,Garbern JY,Kamholz J,Heng H,Hodes ME,Malcolm S,Hobson GM
    Journal: American journal of human genetics
    Go to Genome Browser ( Click the image )