About dbCRID

  • dbCRID (Database of Chromosomal Rearrangements In Diseases) is the largest database of curated database of human Chromosome rearrangements and associated diseases.
  • Current release: v 0.9 (06/30/2010).
  • Please direct questions and comments to dbCRID@biolead.org.
  • Related Databases

  • AtlasGeneticsOncology, Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • ChimerDB 2.0, A knowledgebase for fusion genes updated
  • CytoD 1.0, A database of cytogenetic abnormalities.
  • DACRO, A disease-Associated Chromosomal Rearrangements Online.
  • Decipher, , A Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
  • HYBRIDdb,A database of hybrid genes in the human genome.
  • Mitelman, A database of Chromosome Aberrations and Gene Fusions in Cancer.
  • SKY/M-FISH &CGH, A public platform for investigators to share and compare their molecular cytogenetic data.
  • TICdb, A database of Translocation breakpoints In Cancer.
  • References

  • Kong F, Zhu J, Wu J, Peng J, Wang Y, Wang Q, Fu S, Yuan L and Li T: dbCRID: a database of chromosomal rearrangements in human diseases. Nucleic Acids Res. [PubMed] [Full-text]
  • Introduction

        Chromosome rearrangements (CRs) occur as a consequence of double strand breakage (DSB) of the DNA, followed by abnormal rejoining of the non-homologous ends, producing a new chromosomal arrangement. Alternatively, CRs can occur as a result of crossing-over between repetitive DNA sequences. CR events lead to disruption of genes and other functional structures, and they are implicated in many tumor and non-tumor diseases. In recent years, advances in DNA sequencing technologies and the completion of the human genome have led to accelerated accumulation of information about experimentally identified CR events and their associated disease and/or clinical symptoms. This rich information can provide important clues about the chromosomal breakage and DNA repair mechanisms, and lead to improved understanding about how CR events lead to these important diseases.

        dbCRID is a curated database of human CRs and associated diseases. The current release of dbCRID includes 2,643 individually curated entries of experimentally tested CRs, their associated diseases and/or clinical symptoms, as well as detailed information about the CRs, including the precise locations of the breakpoints, the genes involved, and junction sequences, the experimental techniques applied, and links to the original studies. These data were curated from 1,172 original studies.

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